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专利名称：Anti-anxiety benzothiepino(5,4-c]pyridazines发明人：Toru Nakao,Minoru Kawakami,Minoru
Obata,Kenji Morita
申请号：US07/162935申请日：19880302公开号：US04849421A公开日：190718
摘要：A benzothiepino 5,4-c]pyridazine compound of the formula: ##STR1## whereinR.sup.1 and R.sup.2 are the same or different and each is hydrogen, halogen,trifluoromethyl, hydroxy, amino, nitro, cyano, C. sub. 1-4 alkyl, C.sub.1-4 alkoxy, orC.sub.2-5 alkanoylamino, R.sup.3 is hydrogen, C.sub.1-8 alkyl, hydroxy-C.sub.1-4 alkyl,C.sub.2-5 alkanoyloxy- C.sub.1-4 alkyl, aryl, aryl-C.sub.1-4 alkyl, heteroaryl, or substitutedaryl, aryl-C.sub.1-4 alkyl or heteroaryl by 1 to 3 substituents selected from the groupconsisting of halogen, trifluoromethyl, hydroxy, amino, nitro, cyano, C.sub.1-4 alkyl,C.sub.1- 4 alkoxy and C.sub.2-5 alkanoylamino on the armoatic ring, n is 0, 1 or 2, and thebond between the 4-position and the 4a-position is single bond or double bond.
Said compounds exhibit anti-anxietic activity and are useful as anti-anxiety agent.
申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.
代理机构：Sughrue, Mion, Zinn, Macpeak, and Seas
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