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专利名称：Materials and methods for prevention and
treatment of RNA viral diseases
发明人：Shyam S. Mohapatra,Aruna K. Behera申请号：US104236申请日：20030430公开号：US07354908B2公开日：20080408
摘要：The subject invention concerns a method of inhibiting an RNA virus infectionwithin a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS)activity within the patient. Preferably, the preventative and therapeutic methods of thepresent invention involve administering a nucleotide encoding 2-5 AS, or at least onecatalytically active fragment thereof, such as the p40, p69, p100 subunits, to a patient inneed thereof. The present inventors have determined that overexpression of 2-5AScauses a reduction in epithelial cell damage, reduction in infiltration of mononuclear cellsin the peribronchiolar and perivascular regions, and reduction in thickening of the septa inthe lungs. Levels of chemokines, such as MIP1-α, are also reduced upon overexpressionof 2-5AS. The subject invention also pertains to pharmaceutical compositions containing anucleotide sequence encoding 2-5 AS and a pharmaceutically acceptable carrier, as wellas vectors for delivery of the 2-5 AS nucleotide sequence.
申请人：Shyam S. Mohapatra,Aruna K. Behera
地址：Tampa FL US,Norwood MA US
国籍：US,US
代理机构：Saliwanchik, Lloyd & Saliwanchik
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