Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :SNS-032345627-80-7HY-10008380.53C17H24N4O2S2>98%Solubility:DMSO ≥73mg/mL Water<1.2mg/mL Ethanol ≥73mg/mLMechanisms: Pathways:Cell Cycle/DNA Damage; Target:CDK gyBiological Activity:BMS-387032 is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4,38 and 62 nM respectively). BMS-387032 displays no activity against 190 additional kinases (IC50>1000 nM). BMS-387032 arrests the cell cycle at G2/M; inhibits transcription, proliferation andcolony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. BMS-387032prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.References:[1]. Jones, Clifford D. Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependentkinase inhibitors Bioorganic & Medicinal Chemistry Letters (2008), 18(24), 86-. [2]. Vasiliou, S.; Castaner, R.; Bolos, J. SNS-032 - Cyclin-dependent kinase inhibitor oncolytic Drugsof the Future (2008), 33(11), 932-937.()()[3]. Heath EI, Bible K, Martell RE, Adelman DC, Lorusso PM.A phase 1 study of SNS-032 (formerlyBMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oraldose and weekly infusion in patients with metastatic refractory solid tumors.Invest New Drugs. 2008Feb;26(1):59-65. Epub 2007 Oct 16. [4]. Wu Y, Chen C, Sun X, Shi X, Jin B, Ding K, Yeung SC, Pan J.Cyclin-dependent kinase 7/9inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abloncogene addiction in...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
