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专利名称：Microbiological conversion of sterol
derivatives to 5-androsten- 17-onederivatives and their use
发明人：Alfred Weber,Mario Kennecke,Alfred
Popper,Rudolf Muller,Ulrich Eder,GregorHaffer,Gerhard Sauer,Gunter Neef,RudolfWiechert
申请号：US05/710559申请日：19760730公开号：US04170518A公开日：19791009
摘要：Sterol derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atomand R.sub.2 is lower alkoxy, or R.sub.1 and R.sub.2 collectively are lower alkylenedioxyand R.sub.3 is a sterol hydrocarbon side chain are converted to the correspondingandrosten-17-ones by the oxidative degradation activity of a species of microorganismwhich degrades sterol side chains, preferably of the genus Mycobacterium. The ethergroup of those compounds wherein R.sub.1 is a hydrogen atom and R. sub.2 is loweralkoxy, and the corresponding 17&bgr;-hydroxy and 17. alpha.-hydrocarbon-17&bgr;-hydroxy compounds is cleaved by reaction with an alkanoic acid chloride or anhydride inthe presence of a Lewis acid.
申请人：SCHERING AG
代理机构：Millen & White
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