专利内容由知识产权出版社提供
专利名称：CANCER PLATINUM RESISTANCE
DETECTION AND SENSITIZATION METHOD
发明人：LANCASTER, Jonathan,COTTRILL,
Hope,CHEN, Ning,BLOOM,
Gregory,ESCHRICH, Steven,XIONG,Yin,HUMPHREY, Marcia
申请号：EP09770577.6申请日：20090626公开号：EP2307571A2公开日：20110413
摘要：The phosphorylation status of the BAD protein is a determinant of ovariancancer cell responsiveness to platinum chemotherapy. Indirect manipulation of BADphosphorylation status influences cisplatin sensitivity. BAD phosphorylation represents abiomarker that predicts platinum sensitivity and is a therapeutic target to increaseplatinum sensitivity. The methods employ phospho-specific antibody against a particularamino acid residue or site. Phospho-specific protein characterization methods includeimmunohistochemical (IHC), flow cytometric, immunofluorescent, capture-and- detection,or reversed phase assay.
申请人：University of South Florida,H. Lee Moffitt Cancer Center And ResearchInstitute, Inc.
地址：3802 Spectrum Blvd., Suite 100 Tampa, FL 33612 US,12902 Magnolia DriveTampa, FL 33612 US
国籍：US,US
代理机构：Chaillot, Geneviève
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