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专利名称：Cancer platinum resistance detection and
sensitization method
发明人：Johnathan Lancaster,Douglas C.
Marchion,Dung-Tsa Chen
申请号：US12975970申请日：20101222公开号：US09063143B2公开日：20150623
摘要：The phosphorylation status of the BAD protein is a determinant of ovariancancer cell responsiveness to platinum chemotherapy. Indirect manipulation of BADphosphorylation status influences cisplatin sensitivity. BAD phosphorylation represents abiomarker that predicts platinum sensitivity and is a therapeutic target to increaseplatinum sensitivity. The methods employ phospho-specific antibody against a particularamino acid residue or site. Phospho-specific protein characterization methods includeimmunohistochemical (IHC), flow cytometric, immunofluorescent, capture-and-detection,or reversed phase assay.
申请人：Johnathan Lancaster,Douglas C. Marchion,Dung-Tsa Chen
地址：Tampa FL US,Seminole FL US,Tampa FL US
国籍：US,US,US
代理机构：Smith & Hopen, P.A.
代理人：Robert J. Varkonyi
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