木仓医学考研复试SCI长难句风湿免疫科第一章—系统性红斑狼疮
Inrecentyears,theresearchonthepathogenesisofsystemiclupuserythematosus(SLE)hasbeendeepened,fromthelevelofhistopathologytothecellularandmolecularbiology,thuspromotingtheprogressofSLEdrugtherapeutics.InMarch2011,theUnitedStatesFoodandDrugAdministration(FDA)approvedthehumanizedmonoclonalantibody,BelimumabforthetreatmentofSLE.
近年来，从组织病理学水平到细胞和分子生物学水平，对系统性红斑狼疮(SLE)发病机制的研究不断深入，因此促进了SLE药物治疗的进展。2011年3月，美国食品药品监督管理局(FDA)批准人源化单克隆抗体贝利单抗用于SLE的治疗。知识点总结：①pathogenesis②lupus
③erythematosus④histo-⑤patho-⑥cellular⑦molecular⑧therapeutics⑨mono-n.发病机制n.狼疮，红斑狼疮n.红斑狼疮前缀，组织词缀，病理adj.细胞的adj.分子的n.治疗学前缀，单一
MohamedA,ChenY,WuH,LiaoJ,ChengB,LuQ.TherapeuticadvancesinthetreatmentofSLE.IntImmunopharmacol.2019Jul;72:218-223.木仓医学考研复试SCI长难句风湿免疫科第二章—强直性脊柱炎
Ankylosingspondylitisisaninsidiouslyprogressiveanddebilitatingformofarthritisinvolvingtheaxialskeleton.Thelongdelayindiagnosisandinsufficientresponsetocurrentlyavailabletherapeuticsbothadvocateforagreaterunderstandingofdiseasepathogenesis.Genome-wideassociationstudiesofthishighlygeneticdiseasehaveimplicatedspecificimmunepathways,includingtheinterleukin(IL)-17/IL-23pathway,controlofnuclearfactorkappaB(NF-κB)activationandothergenescontrollingCD8andCD4Tcellsubsets.
强直性脊柱炎是一种累及中轴骨的隐匿的渐进性衰竭性关节炎。诊断上的延误、现有治疗方法的应答不理想都要求对疾病的发病机制有更深入的了解。这种高度遗传的疾病的全基因组关联研究已经涉及特异性免疫途径,包括白介素(IL)-17/IL-23通路,核转录因子kappaB(NF-κB)激活的控制和其他的控制CD8和CD4T细胞的基因。知识点总结：①ankylosing②spondyl③-itis④insidiously⑤debilitating⑥axial⑦advocatefor⑧genome-wide⑨implicate
n.强制性n.脊柱后缀，...炎adv.隐匿地adj.使衰弱的adj.轴向的主张n.全基因组v.牵连
SmithJA.Updateonankylosingspondylitis:currentconceptsinpathogenesis.CurrAllergyAsthmaRep.2015Jan;15(1):4.⑩interleukin⑪nuclear⑫subset
SmolenJS,AletahaD,22;388(10055):2023-2038.McInnesn.白介素
adj.细胞核的
n.子集
IB.Rheumatoidarthritis.Lancet.2016Oct木仓医学考研复试SCI长难句风湿免疫科第三章—类风湿性关节炎
Rheumatoidarthritisisachronicinflammatoryjointdisease,whichcancausecartilageandbonedamageaswellasdisability.Earlydiagnosisiskeytooptimaltherapeuticsuccess,particularlyinpatientswithwell-characterisedriskfactorsforpooroutcomessuchashighdiseaseactivity,presenceofautoantibodies,andearlyjointdamage.Treatmentalgorithmsinvolvemeasuringdiseaseactivitywithcompositeindices,applyingatreatment-to-targetstrategy,anduseofconventionalantirheumaticdrugs.
类风湿关节炎是一种慢性炎症性关节疾病，可导致软骨和骨骼损伤，甚至残疾。早期诊断是达到最佳治疗效果的关键，特别是对于那些具有不良预后特征的危险因素的患者，比如疾病活动性高、存在自身抗体和关节早期损伤。治疗流程包括用综合指数测量疾病活动度，应用目标治疗策略，以及使用常规抗风湿药。知识点总结：①rheumatoid②inflammatory③cartilage④joint⑤algorithm⑥composite
adj.类风湿的adj.炎症性的n.软骨n.关节
n.算法，运算法则adj.复合的
SmolenJS,AletahaD,22;388(10055):2023-2038.McInnesIB.Rheumatoidarthritis.Lancet.2016Oct木仓医学考研复试SCI长难句风湿免疫科第四章—干燥综合征
Sjogren'ssyndrome(SS)isthe2ndmostcommonchronicautoimmunerheumaticdiseaseandassociatedwithahighburdenofillness.Morbidityarisesnotonlyfromuntreatedxerostomiaandkeratoconjunctivitisbutalso
fromextra-glandularmanifestations
includingthedevelopmentofnon-Hodgkin'sBcelllymphomas.
干燥综合征(SS)是第二常见的慢性自身免疫性风湿病，疾病负担重。该病的发病不仅始于未经治疗的口干症和角膜结膜炎，而且还具有腺外表现，包括非霍奇金B细胞淋巴瘤的发生。知识点总结：
①Sjogren'ssyndrome②xerostomia③kerato-④conjunctiva⑤glandular⑥manifestation⑦lymphoma
干燥综合征n.口腔干燥前缀，角膜n.结膜adj.腺的，腺状的n.临床表现n.淋巴瘤
SmolenJS,AletahaD,22;388(10055):2023-2038.McInnesIB.Rheumatoidarthritis.Lancet.2016Oct
