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专利名称：COMPOSITIONS AND METHODS FOR
PRODUCING CHEMICALS AND DERIVATIVESTHEREOF
发明人：KAMBOURAKIS, Spiros,GRIFFIN, Benjamin,
M.,MARTIN, Kevin, V.
申请号：EP157217.4申请日：20150320公开号：EP31199A4公开日：20171129
摘要：The present invention provides methods for producing a product of one ormore enzymatic pathways. The pathways used in the methods of the invention involveone or more conversion steps such as, for example, an enzymatic conversion of guluronicacid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketohexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the inventionproduce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include bothenzymatic and chemical conversions as steps. Various pathways are also provided forconverting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucoseinto 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineeredenzymes that perform reactions with high specificity and efficiency. Additional productsthat can be produce include metabolic products such as, but not limited to, guluronicacid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using
glucose as a substrate or using any intermediate in any of the methods or pathways ofthe invention.
申请人：Synthetic Genomics, Inc.
地址：11149 N. Torrey Pines Rd, Suite 100 La Jolla, CA 92037 US
国籍：US
代理机构：Cornish, Kristina Victoria Joy
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