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专利名称：Inactivation resistant factor VIII
发明人：Randal J. Kaufman,Steven W. Pipe,Kagehiro
Amano
申请号：US09819098申请日：20010411公开号：US06838437B2公开日：20050104
专利附图：
摘要：The present invention provides novel purified and isolated nucleic acid
sequences encoding procoagulant-active FVIII proteins. The nucleic acid sequences of thepresent invention encode amino acid sequences corresponding to known human FVIII
sequences, wherein residue Phe3O9 is mutated. The nucleic acid sequences of thepresent invention also encode amino acid sequences corresponding to known humanFVIII sequences, wherein the APC cleavage sites, Arg336 and Ile562, are mutated. Thenucleic acid sequences of the present invention further encode amino acid sequencescorresponding to known human FVIII sequences, wherein the B-domain is deleted, thevon Willebrand factor binding site is deleted, a thrombin cleavage site is mutated and anamino acid sequence spacer is inserted between the A2- and A3-domains. Methods ofproducing the FVIII proteins of the invention, nucleotide sequences encoding suchproteins, pharmaceutical compositions containing the nucleotide sequences or proteins,as well as methods of treating patients suffering from hemophilia, are also provided.
申请人：Randal J. Kaufman,Steven W. Pipe,Kagehiro Amano
地址：Ann Arbor MI US,Ypsilanti MI US,Tokyo JP
国籍：US,US,JP
代理机构：Lahive & Cockfield, LLP
代理人：DeAnn F. Smith, Esq.
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