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专利名称：Methods of prevention and treatment of
ischemic damage
发明人：James W. Simpkins,Douglas F. Covey申请号：US09372627申请日：19990811公开号：US06350739B1公开日：20020226
摘要：The present invention in various embodiments provides methods of treatingstroke and conferring protection on a population of cells associated with ischemia in asubject following an ischemic event, comprising: (a) providing an estrogen compound; and(b) administering the effective amount of the compound over a course that includes atleast one dose within a time that is effectively proximate to the ischemic event, so as toconfer protection on the population of cells. Novel methods are provided for thedelivery of an estrogen compound. Examples of ischemic events treatable according tothe invention are cerebrovascular disease or stroke, subarachnoid subhemorrhage,myocardial infarct, surgery and trauma. A method of treating ischemic damage utilizinghormones that are non-sex hormones is also provided. A method of treating stroke withent-17&bgr;-estradiol, and a method of synthesis, and compounds produced from thesynthesis are provided.
申请人：UNIVERSITY OF FLORIDA RESARCH FOUNDATION, INC.,WASHINGTONUNIVERSITY
代理机构：Bromberg & Sunstein LLP
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