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专利名称：Alpha-substituted pyrimidine-thioalkyl and
alkylether compounds as inhibitors of viralreverse transcriptase
发明人：Richard A. Nugent,Stephen T.
Schlachter,Michael J. Murphy,JoelMorris,Richard C. Thomas,Donn G.Wishka,Gary J. Cleek,David R. Graber
申请号：US08/945153申请日：19971017公开号：US06043248A公开日：20000328
摘要：The subject invention relates to pyrimidine-thioalkyl and alkylether compoundsof Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely thecompounds of Formula (I) where R. sub.4 is selected from the group consisitng of --H or --NR.sub.15 R.sub. 16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1- pyrrolidino, 1-morpholino or 1-piperidino; and R.sub.6 is selected from the group consisting of --H, orhalo (preferably --Cl); with the overall proviso that R.sub.4 and R.sub.6 are not both --H.The compounds of Formula (IA) are useful in the treatment of individuals who are HIVpositive being inhibitors of viral reverse transcriptase. ##STR1##
申请人：PHARMACIA & UPJOHN COMPANY
代理人：Andrew M. Solomon
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