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专利名称：ANTIBODIES AGAINST SIGNAL-REGULATORY PROTEIN ALPHA ANDMETHODS OF USE
发明人：PONS, Jaume,SIM, Bang Janet,WAN,
Hong,KUO, Tracy Chia-Chien,KAUDER, StevenElliot,HARRIMAN, William Don,IZQUIERDO,Shelley
申请号：EP17853838.5申请日：20170920公开号：EP3515490A1公开日：20190731
摘要：Provided herein, inter alia, are isolated antibodies that bind an extracellulardomain of a human SIRP-α v1 polypeptide (e.g., the D1 domain), an extracellular domainof a human SIRP-α v2 polypeptide, or both. In some embodiments, the antibodies alsobind an extracellular domain of a monkey SIRP-α polypeptide, an extracellular domain ofa mouse SIRP-α polypeptide, an extracellular domain of a human SIRP-β polypeptide,and/or an extracellular domain of a human SIRP-γ polypeptide. In some embodiments,the antibodies block or do not binding between an extracellular domain of a human SIRP-α polypeptide and an IgSF domain of a human CD47 polypeptide, while in someembodiments, the antibodies reduce the affinity of a human SIRP-α polypeptide forbinding an IgSF domain of a human CD47 polypeptide. Further provided herein aremethods, polynucleotides, vectors, and host cells related thereto.
申请人：ALX Oncology Inc.
地址：866 Malcolm Road, Suite 100 Burlingame, CA 94010 US
国籍：US
代理机构：J A Kemp
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