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DNA molecule encoding prokaryotic prolylendopeptid

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专利名称:DNA molecule encoding prokaryotic

prolylendopeptidase

发明人:Tetsuya Inaoka,Toshio Kokubo,Daisuke

Tsuru,Tadashi Yoshimoto

申请号:US08/2276申请日:19940414公开号:US05521081A公开日:19960528

摘要:The invention concerns DNA encoding prolylendopeptidase, hybrid vectorscontaining such DNA, transformed hosts capable of expressing prolylendopeptidase, aprocess for the production of prolylendopeptidase including the steps of: culturing ahost organism transformed with an expression vector including a DNA coding forprolylendopeptidase and optionally, recovering the produced prolylendopeptidase; anda process for the production of a C-terminal amidated peptide from two precursors,including the steps of: placing the two precursors in contact with a prolylendopeptidasein a medium to convert the precursor peptides to the C-terminal amidated peptide, andrecovering the resulting C-terminal amidated peptide.

申请人:CIBA-GEIGY (JAPAN) LIMITED

代理机构:Wenderoth, Lind & Ponack

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