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Methods and compositions useful for inhibition of

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专利名称:Methods and compositions useful for

inhibition of alpha v beta 5 mediatedangiogenesis

发明人:Peter Brooks,David A. Cheresh,Martin

Friedlander

申请号:US112906申请日:20051129

公开号:US20060165703A1公开日:20060727

摘要:The present invention describes methods for inhibiting angiogenesis in tissuesusing vitronectin αβantagonists. The αβ-mediated angiogenesis is correlated withexposure to cytokines including vascular endothelial growth factor, transforming growthfactor-α and epidermal growth factor. Inhibition of αβ-mediated angiogenesis isparticularly preferred in vascular endothelial ocular neovascular diseases, in tumorgrowth and in inflammatory conditions, using therapeutic compositions containingαβantagonists.

申请人:Peter Brooks,David A. Cheresh,Martin Friedlander

地址:Carmel NY US,Encinitas CA US,Del Mar CA US

国籍:US,US,US

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