Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Metoclopramide364-62-5HY-17382299.80C14H22ClN3O2>98%ySolubility:DMSOMechanisms: Pathways:GPCR/G protein; Target:Dopamine Receptor Pathways:Neuronal Signaling; Target:Dopamine Receptor Biological Activity:Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic.MetoclopramideisadopamineD2antagonistthatisusedasanantiemetic IC50 Value: Target: D2 Receptor Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety ofgastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is theantiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety ofmetoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting duringpregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) andgastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptorgpgpppppantagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist....References:[1]. Navari RM, Nagy CK, Gray SE. The use of olanzapine versus metoclopramide for the treatmentof breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenicchemotherapy. Support Care Cancer. 2013 Jan 12. [2]. Gutiérrez-Hermosillo H, Díaz de León-González E, Beltrán Santiago D et al. Metoclopramide asa risk factor for postprandial hyperglycemia in type 2 diabetes. Nutr Hosp. 2012 Jul-Aug;27(4):1267-71. [3]. Ilan Matok, Sc.Pharm., Rafael Gorodischer, et al. The Safety of Metoclopramide Use in the FirstTrimester of Pregnancy. N Engl J Med 2009; 360:2528-2535. [4]. DN Bateman, C Kahn, K Mashiter, DS Davies. Pharmacokinetic and concentration-effect studieswith intravenous metoclopramide. British Journal of Clinical Pharmacology.1978,6(5): 401-407 ...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.comT 18 Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr