专利名称：CANCER PLATINUM RESISTANCE
DETECTION AND SENSITIZATION METHOD
发明人：LANCASTER, JOHNATHAN M.,MARCHION,
DOUGLAS C.,CHEN, DUNG-TSA
申请号：EP09770577申请日：20090626公开号：EP2307571A4公开日：20120307
摘要：The phosphorylation status of the BAD protein is a determinant of ovariancancer cell responsiveness to platinum chemotherapy. Indirect manipulation of BADphosphorylation status influences cisplatin sensitivity. BAD phosphorylation represents abiomarker that predicts platinum sensitivity and is a therapeutic target to increaseplatinum sensitivity. The methods employ phospho-specific antibody against a particularamino acid residue or site. Phospho-specific protein characterization methods includeimmunohistochemical (IHC), flow cytometric, immunofluorescent, capture-and- detection,or reversed phase assay.
申请人：UNIVERSITY OF SOUTH FLORIDA,H. LEE MOFFITT CANCER CENTER ANDRESEARCH INSTITUTE, INC.
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