专利名称：METHODS AND INTERMEDIATES FOR
SYNTHESIS OF SELECTIVE DPP-IVINHIBITORS
发明人：CAMPBELL, David Alan,LEITAO, Emilia
P.t.,WU, Zhen-ping,WANG, Peng
申请号：EP08743692.9申请日：20080305公开号：EP2173709A2公开日：20100414
摘要：Methods and intermediates for the synthesis of selective inhibitors of
dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may bedeblocked to yield the medicinal compound. The carboxylate salt can be a crystallineform of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in thetreatment of diabetes.
申请人：Phenomix Corporation
地址：5930 Cornerstone Court West, Suite 230 San Diego, CA 92121 US
国籍：US
代理机构：Fagerlin, Heléne
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