专利名称：ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER
COMPOUNDS AS INHIBITORS OF VIRALREVERSE TRANSCRIPTASE
发明人：NUGENT, Richard, A.,WISHKA, Donn,
G.,CLEEK, Gary, J.,GRABER, David,
R.,SCHLACHTER, Stephen, Thomas,MURPHY,Michael, J.,MORRIS, Joel,THOMAS, Richard, C.
申请号：EP96913306.5申请日：19960503公开号：EP0824524B1公开日：20040908
摘要：The subject invention relates to pyrimidine-thioalkyl and alkylether compoundsof Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely thecompounds of Formula (I) where R4 is selected from the group consisitng of -H or-NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, NH2 or R15 and R16 taken togetherwith the -N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R6 is selected from thegroup consisting of -H, or halo (preferably -Cl); with the overall proviso that R4 and R6are not both -H. The compounds of Formula (IA) are useful in the treatment of individualswho are HIV positive being inhibitors of viral reverse transcriptase.
申请人：UPJOHN CO
地址：US
国籍：US
代理机构：Perry, Robert Edward
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