9-Deoxy-9&agr;-hydroxymethyl-PGF.sub.2 analogs

专利名称：9-Deoxy-9&agr;-hydroxymethyl-PGF.sub.2

analogs

发明人：Gordon L. Bundy申请号：US05/651622申请日：19760123公开号：US04021467A公开日：19770503

摘要：The disclosure includes novel cyclic ethers of the formulas: ##STR1## In theseformulas, X and Y are --O-- or a valence bond with the proviso that one of X and Y is --O--and the other is a valence bond; R is hydrogen, alkyl of one to 4 carbon atoms; inclusive,or a pharmacologically acceptable cation; R.sub.2 and R.sub.3 are hydrogen, methyl, orethyl; and A is ##STR2## wherein R.sub.4 is hydrogen, methyl, or ethyl with the provisothat R.sub.2 and R.sub.3 are both hydrogen when R.sub.4 is methyl or ethyl. The

compounds of the first of these formulas are useful as vasoconstrictors and enhancers ofplatelet aggregation, and are useful in the control of bleeding in mammals, includingman. The compounds of the second of these formulas are useful in the treatment ofinflammation.

申请人：THE UPJOHN COMPANY

代理人：Earl C. Spaeth,Robert A. Armitage

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