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专利名称：USE OF PHOSPHODIESTERASE 5A
INHIBITORS FOR THE TREATMENT OFMUSCULAR DYSTROPHY
发明人：Ronald G. Victor,Gail D. Thomas申请号：US14782883申请日：20140421
公开号：US20160067246A1公开日：20160310
摘要：Described herein are methods of treating muscular dystrophy, includingBecker's muscular dystrophy and Duchenne muscular dystrophy. The methods compriseadministering a phosodiesterase 5A (PDE5A) inhibitor, such as tadalafil, to a subject inneed thereof. Administering the PDE5A inhibitor has beneficial effects such as restoringfunctional sympatholysis, alleviating ischemic insult to dystrophin-deficient musclemembranes, reducing use-dependent muscle injury, and thus can slow musculardystrophy disease progression.
申请人：CEDARS-SINAI MEDICAL CENTER
地址：Los Angeles CA US
国籍：US
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