专利内容由知识产权出版社提供
专利名称：Osmotically driven active agent delivery
device providing an ascending releaseprofile
发明人：Guohua Chen,Rupal A. Ayer,Scott
Lautenbach
申请号：US109535申请日：20040929公开号：US07241457B2公开日：20070710
专利附图：
摘要：In one aspect, the present invention is directed to an osmotic pump that
automatically provides an ascending release rate of active agent as the osmotic pumpfunctions in an environment of operation and may be designed for implantation within adesired animal or human subject. An osmotic pump according to the present inventionincludes a reservoir, a rate controlling membrane, an expandable osmotic composition, anactive agent formulation and an exit orifice. Once administered to an environment ofoperation, water passes through the rate controlling membrane and into the osmoticcomposition, which causes the osmotic composition to expand and expel the active agentformulation through the exit orifice at a rate that is directly proportional to the rate atwhich water passes through the rate controlling membrane. An osmotic pump accordingto the present invention permits the flow of water through the rate controllingmembrane to increase automatically without the need for manipulation of the osmoticpump after administration. As the flow of water through the rate controlling membraneincreases, the rate at which active agent is delivered from the osmotic pump will alsoincrease proportionally.
申请人：Guohua Chen,Rupal A. Ayer,Scott Lautenbach
地址：Sunnyvale CA US,Cupertino CA US,San Mateo CA US
国籍：US,US,US
代理机构：TraskBritt
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